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目的:研究慢性高原病患者及高原健康人群血清干细胞因子水平,探讨干细胞因子在慢性缺氧条件下的病理及生理意义。方法:采用双抗体夹心酶联免疫吸附法测定20例慢性高原病患者(慢性高原病组),22例世居青海省玉树市健康藏族(世居组),24例移居玉树市汉族组(移居组),24例世居青海西宁市汉族健康人(对照组)血清干细胞因子水平并进行比较,分析干细胞因子与各组实验室指标的相关性。结果:1各组血清干细胞因子含量有显著性差异(F=2.281,P<0.05),其中慢性高原病组(843.4±159.3)pg/m L与世居藏族组(975.9±120.0)pg/m L比较差异有统计学意义(P<0.05),世居藏族与对照组比较,差异有统计学意义(975.9±120.0)pg/m L vs(865.0±148.4)pg/m L,P<0.05;2各组血清干细胞因子水平与Hb和SaO_2之间均无相关性。结论:干细胞因子可能在高原适应的机制中发挥重要作用,加强SCF在高原低氧环境下的研究,可能为慢性高原病的防治提供新的研究方向。
Objective: To study the serum levels of stem cell factor in patients with chronic mountain sickness and healthy people in high altitude, and to explore the pathological and physiological significance of stem cell factor under chronic hypoxia. Methods: Twenty patients with chronic high altitude disease (chronic high altitude sickness), 22 healthy native Tibetans (YJU) living in Yushu City, Qinghai Province and 24 immigrants from Yushu City Group), and 24 healthy Han people (control group) living in Xining City, Qinghai Province for comparison. The correlation between stem cell factor and laboratory indexes was analyzed. Results: 1 There were significant differences in the serum levels of Stem Cell Factors (F = 2.281, P <0.05), among which 843.4 ± 159.3 pg / m L and 975.9 ± 120.0 pg / m (P <0.05). Compared with the control group, the difference was statistically significant (975.9 ± 120.0) pg / m L vs (865.0 ± 148.4) pg / m L, P <0.05; There was no correlation between serum levels of Stem cells and Hb and SaO_2 in all groups. CONCLUSIONS: Stem cell factor may play an important role in the mechanism of plateau adaptation. Strengthening the study of SCF under plateau hypoxia may provide a new research direction for the prevention and treatment of chronic mountain sickness.