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目的:观察鸦胆子油乳联合艾迪注射液配合化疗治疗晚期非小细胞肺癌的临床疗效。方法:将非小细胞肺癌患者70例按照随机数字表法分为2组各35例,2组均接受化疗方案,治疗组在化疗前2天给予鸦胆子油乳注射液以及艾迪注射液治疗。化疗期间检查患者肝肾功能、心电图,观察病情的变化、临床疗效及不良反应。评估临床疗效。结果:化疗有效率治疗组为57.1%,对照组为45.7%,2组比较,差异无显著性意义(P>0.05)。2组中位生存期、1年生存率比较,差异均无显著性意义(P>0.05)。生活质量改善率治疗组为80.0%,对照组为45.7%,2组比较,差异有显著性意义(P<0.05)。2组间的白细胞减少、血红蛋白减少、血小板减少、恶心呕吐的发生率比较,差异均有显著性意义(P<0.05)。结论:鸦胆子油乳联合艾迪注射液配合化疗治疗晚期非小细胞肺癌,可以降低毒副作用,提高患者生活质量。
Objective: To observe the clinical effect of Brucea javanica oil combined with Aidi injection and chemotherapy in the treatment of advanced non-small cell lung cancer. Methods: Seventy patients with non-small cell lung cancer were divided into two groups of 35 according to the random number table. The two groups received chemotherapy. The treatment group received Brucea javanica oil injection and Aidi injection two days before chemotherapy . Chemotherapy during liver and kidney function tests, ECG, observation of the disease changes, clinical efficacy and adverse reactions. Evaluate clinical efficacy. Results: The effective rate of chemotherapy was 57.1% in the treatment group and 45.7% in the control group. There was no significant difference between the two groups (P> 0.05). There was no significant difference in median survival time and 1-year survival rate between the two groups (P> 0.05). The quality of life improvement rate was 80.0% in the treatment group and 45.7% in the control group. There was significant difference between the two groups (P <0.05). The incidence of leukopenia, hemoglobin decrease, thrombocytopenia and nausea and vomiting in the two groups were significantly different (P <0.05). Conclusion: Brucea javanica oil combined with Aidi injection and chemotherapy for advanced non-small cell lung cancer can reduce the side effects and improve the quality of life of patients.