论文部分内容阅读
程序性细胞死亡(凋亡)在胚胎发生、成熟器官的自身稳定以及包括癌症在内的许多疾病中起重要作用,正是细胞死亡与增殖的平衡才使恰当的细胞数量及其类型得以保持。凋亡有其特有的形态学、生化学上的变化。bcl-2基因在恶性B细胞淋巴瘤中异常表达并能抑制细胞凋亡,是最早被报道参与凋亡调控的基因之一。近年来相继报道的与bcl-2有同源序列的基因,在凋亡正、反两方面的调控上起重要作用。目前,这一bcl-2基因家族至少有另外8个成员——bax,bcl-x,mcl-1,A1,Bak,NR13,ced-9和Bfl-1,它们主要是通过与bcl-2重要功能区如BH1和BH2等在氨基酸序列上
Programmed cell death (apoptosis) plays an important role in embryogenesis, self-stability in mature organs, and many diseases, including cancer, and it is the balance of cell death and proliferation that keeps the proper number of cells and their types preserved. Apoptosis has its own unique morphological and biochemical changes. The bcl-2 gene is abnormally expressed in malignant B-cell lymphoma and can inhibit apoptosis. It is one of the earliest genes reported to be involved in the regulation of apoptosis. In recent years have been reported with bcl-2 have homologous sequences of genes, apoptosis in the positive and negative aspects play an important role in the regulation. At present, at least eight other members of the bcl-2 gene family - bax, bcl-x, mcl-1, A1, Bak, NR13, ced-9 and Bfl-1, are currently predominantly associated with bcl-2 Functional domains such as BH1 and BH2 are on the amino acid sequence