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棉酚是一种有效的非甾体男性避孕药,它可抑制能量代谢的许多酶,包括ATP酶和脱氢酶,棉酚还可引起精子超微结构的广泛损伤(细胞膜、线粒体和轴丝)。但其作用的精确机制尚不清楚,棉酚的抗生精作用通过二种不同的机制:对生精上皮的直接影响及增加性腺前列腺素(PG)的生物合成。阿斯匹林是PG合成抑制剂,它可拮抗棉酚引起的PG合成的增加且在一定程度上使精子免受棉酚的损伤。本文中作者报告了以棉酚合并PG或阿斯匹林对大鼠睾丸的影响。研究采用42只成年雄性Sprague Dawley大鼠,体重约250克,分成6组,置于标准的大鼠笼内,室温24℃,光照每天12小时,随意进食和饮
Gossypol is a potent non-steroidal male contraceptive that inhibits many of the enzymes involved in energy metabolism, including ATPase and dehydrogenase, which can cause extensive damage to the ultrastructure of sperm (cell membranes, mitochondria, and axons ). However, the exact mechanism of action is unclear. The antimicrobial effect of gossypol is mediated by two different mechanisms: direct effects on the seminiferous epithelium and increased biosynthesis of gonadotropin (PG). Aspirin is a PG synthesis inhibitor that antagonizes gossypol-induced increases in PG synthesis and to some extent protects sperm from gossypol. In this paper, the authors report the effects of gossypol combined with PG or aspirin on rat testis. Forty-two adult male Sprague Dawley rats, weighing approximately 250 grams and divided into 6 groups, were housed in a standard rat cage at room temperature of 24 ° C and exposed to light for 12 hours a day