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目的:高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究。方法:选择43例脑出血患者及30例对照组患者,用酶联免疫法检测其入院后第1、2、3、5、7天的血浆脂联素浓度及入院时白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)浓度,放射免疫法检测高敏C-反应蛋白(CRP)浓度,分析高血压脑出血后血浆脂联素与炎症因子之间的相关性。结果:患者脑出血后,血浆脂联素浓度在6 h内明显升高,在24 h达高峰,持续2 d后逐渐下降。实验组血浆脂联素浓度、CRP、IL-6及TNF-α均不同程度高于对照组。相关分析显示血浆脂联素浓度与炎症因子之间呈正相关。结论:高血压脑出血患者血浆脂联素呈动态变化过程,且可能与CRP、IL-6及TNF-α共同参与了脑出血后的炎症反应,是脑出血后脑组织损伤的重要机制之一。
AIM: To study the changes of plasma adiponectin concentration in hypertensive intracerebral hemorrhage and its correlation with inflammatory cytokines. Methods: Forty-three patients with cerebral hemorrhage and 30 control subjects were enrolled in this study. Plasma concentrations of adiponectin and plasma interleukin-6 (IL- 6, TNF-α and radioimmunoassay were used to detect the concentration of high sensitive C-reactive protein (CRP). The correlation between plasma adiponectin and inflammatory cytokines was analyzed after hypertensive intracerebral hemorrhage. Results: After intracerebral hemorrhage, plasma adiponectin concentration increased significantly within 6 h and peaked at 24 h, then decreased gradually after 2 d. Plasma adiponectin concentrations, CRP, IL-6 and TNF-α in the experimental group were all higher than those in the control group. Correlation analysis showed a positive correlation between plasma adiponectin concentration and inflammatory cytokines. CONCLUSION: The plasma adiponectin in patients with hypertensive intracerebral hemorrhage has a dynamic process of change and may be involved in the inflammatory reaction after intracerebral hemorrhage with CRP, IL-6 and TNF-α, which is one of the important mechanisms of cerebral injury after intracerebral hemorrhage.