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目的 研究重组葡激酶(r-SAK)静脉给药后在健康人体内的药代动力学。方法 9例健康成人每人给药10mg(先静脉推注1 mg，2 min内推完，余下9mg 30min内推完)，采血时间为开始给药后的1、10、20、30、35、40、50、60、70、90、120、210和270 min。以双夹心酶联免疫吸附法检测血药浓度：结果 中心室分布容积为(4.45±1.62)L，药-时曲线下面积(AUC)为(89 935±13 228)min·ng/ml，药物总清除率为(6.30±1.05)L／h，T(分布相半衰期)为(13.30±2.06)min，T(消除相半衰期)为(67.94±21.39)min。结论 r-SAK在健康人体内的药代动力学类型符合二室模型。建议临床给药方式为10mgr-SAK 30min内静脉输注，必要时在第1次给药结束后30～60min可再给10mg。“,”Objective To study the pharnacokinetics of r-SAK by intravenous administration in healthy chinese subjects.Methods 10 mg of r-SAK were separately given to 9 subjects (first 1 mg in 2 min,then 9 mg in 30 min).The times of taking blood were 1、10、20、30、35、40、50、60、70、90、120 and 270 min after intravenous administration.The plasma concentration of r-SAK were detected by sandwich ELISA.Results The pharmacokinetics parameters Vc,AUC CL.T and T were (4.45±1.62) L,(89 939±13 228) min·ng/ml,(6.30±1.05) L/h,(13.30±2.06) min and (67.94±21.39) min respectively.Conclusion The pharmacokinetics of r-SAK was adapted to two-corapartent model and intravenous administration of 10 mg r-SAK in 30 minuts is suggested,if necessary,after 30 to 60 minutes once again will be available.