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[背景]全氟烷基物质(PFASs)是一类人工合成的化合物,广泛应用于工业中,并且在人体内常能检测到。PFASs可以干扰孕鼠和胎鼠的甲状腺激素稳态。人体中,在整个孕期由母体的甲状腺激素供给胎儿,甲状腺激素在胎儿的生长和神经发育中起着至关重要的作用。[目的]研究孕妇PFAS暴露与孕妇及新生儿的甲状腺激素状态之间的相关性。[方法]在台湾的一项环境暴露与健康研究中,测量285名妊娠晚期孕妇体内9种PFASs和4种甲状腺激素的血清浓度,并同时测定116名新生儿脐带血血清甲状腺激素的水平。采用多元线性回归模型研究孕妇血清PFASs与孕妇和脐带血甲状腺激素之间的相关性。[结果]全氟己磺酸的浓度与孕妇促甲状腺激素(TSH)的水平呈正相关。血清中全氟壬酸(PFNA)、全氟十一烷酸(PFUnDA)和全氟十二烷酸(PFDoDA)浓度较高的孕妇,其游离甲状腺素(T4)和总T4水平较低。例如,孕妇血清中PFNA每增加1 ng/mL,孕妇的游离T4水平下降0.19 ng/L(95%CI:-0.028~-0.009)。最后,孕妇PFNA、PFUnDA和PFDoDA水平与较低的脐带血总三碘甲状腺氨酸(T3)和总T4水平相关;孕妇全氟癸酸(PFDeA)水平与较低的脐带血总T3水平相关。[结论]上述研究结果表明,妊娠期某些PFASs暴露可能会干扰孕妇和胎儿甲状腺激素的稳态。
[Background] Perfluoroalkyl materials (PFASs) are a class of synthetic compounds that are widely used in industry and are often detectable in the human body. PFASs can interfere with thyroid hormone homeostasis in pregnant and fetal rats. In the body, the fetus is fed by the parent thyroid hormone throughout pregnancy, and thyroid hormones play a crucial role in fetal growth and neurodevelopment. [Objective] To study the correlation between PFAS exposure in pregnant women and thyroid hormone status in pregnant women and newborns. [Method] In a study of environmental exposure and health in Taiwan, serum concentrations of 9 PFASs and 4 thyroid hormones were measured in 285 pregnant women of the third trimester, and the levels of serum thyroid hormone in 116 neonates were measured at the same time. Multivariate linear regression model was used to study the correlation between serum PFASs in pregnant women and pregnant women and umbilical cord blood thyroid hormones. [Results] The concentration of perfluorohexylsulfonic acid was positively correlated with the level of thyroid stimulating hormone (TSH) in pregnant women. Pregnant women with high concentrations of PFNA, PFUnDA and PFDoDA have lower serum T4 and total T4 levels. For example, for every 1 ng / mL increase in PFNA in pregnant women, the level of free T4 in pregnant women decreased by 0.19 ng / L (95% CI: -0.028 to -0.009). Finally, the levels of PFNA, PFUnDA and PFDoDA in pregnant women were associated with lower cord blood total triiodothyronine (T3) and total T4 levels; the level of PFDeA in pregnant women was associated with lower total cord blood T3 levels. [Conclusion] The above results show that some PFASs during pregnancy may interfere with the steady state of thyroid hormone in pregnant women and fetus.