论文部分内容阅读
目的:研究4种临床常用的抗菌药对细菌释放内毒素的影响,为临床使用抗菌药提供理论依据。方法:选择4种抗菌药以1倍、10倍及100倍MIC浓度作用于敏感的肺炎克雷伯菌,测定作用4 h之后释放内毒素的量,并做阴性对照。结果:4种抗菌药中,阿洛西林钠、阿莫西林钠/克拉维酸钾诱导细菌释放内毒素量最大,头孢哌酮次之,异帕米星较低;细菌释放内毒素量1倍MIC>10倍MIC和100倍MIC。结论:不同的抗菌药诱导细菌释放内毒素的量不同,临床选用抗菌药时应参考细菌释放内毒素的特性,合理选用抗菌药。
Objective: To study the effects of four antibacterials commonly used in clinical practice on the release of endotoxin from bacteria and to provide a theoretical basis for the clinical use of antibacterials. Methods: Four kinds of antibacterial agents were selected to be sensitive to Klebsiella pneumoniae at concentrations of 1, 10 and 100 times MIC. The amount of endotoxin released after 4 hours of treatment was determined and used as a negative control. Results: Among the four antibacterials, the concentrations of azlocillin sodium, amoxicillin sodium and potassium clavulanate were the highest in endotoxin released by bacteria, followed by cefoperazone followed by ispamimin, and the bacterial release of endotoxin was 1 time MIC> 10-fold MIC and 100-fold MIC. Conclusion: Different antibacterial agents induce different amounts of endotoxin released by bacteria. In clinical use of antibacterial agents, the characteristics of endotoxin release by bacteria should be consulted, and antibacterial agents should be selected reasonably.