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脑血管疾病是系统性红斑狼疮(SLE)的重要并发症。作者对患SLE并发较大的脑动脉闭塞引起缺血性脑血管疾病的病人作了系统的研究。对象为经作者诊治的6例和从文献上搜集的24例共计30例病人。所有病例都符合有关诊断标准。 结果 临床特征:病人平均年龄35岁(21～52岁),女与男之比为26∶4。至少有26例(86％)脑血管闭塞发生在SLE活动期,3例在SLE初期,1例在缓解期。发生脑血管病之前SLE的病程平均为4.4年(0～15年)。卒中发作时1例在妊娠期,发作前3例有自然流产史,2例有深静脉血栓形成,1例髂总动脉闭塞,1例趾坏疽。大多数病人(18例,60％)以
Cerebrovascular disease is an important complication of systemic lupus erythematosus (SLE). The authors systematically studied patients with SLE complicated by large cerebral artery occlusion-causing ischemic cerebrovascular disease. Subjects were reviewed by the author in 6 cases and collected from the literature of 24 cases a total of 30 patients. All cases met the diagnostic criteria. Results Clinical features: The average age of patients was 35 years old (21 to 52 years old), the ratio of female to male was 26: 4. Cerebral vascular occlusion occurred in at least 26 (86%) of the patients during SLE, 3 in early SLE and 1 in remission. The duration of SLE before cerebrovascular disease averaged 4.4 years (0-15 years). One patient had a history of spontaneous abortion in the first trimester of stroke, one had a history of spontaneous abortion, two had deep vein thrombosis, one had a common iliac artery occlusion and one had a toe gangrene. Most patients (18 patients, 60%) with