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本文报道,用高压液相层析法测定速尿(Ⅰ)在水溶液中的含量和稳定性较美国药典第19版法灵敏而精确。将市售速尿溶液剂分别贮于室温,45°,65°和85°等四种不同温度时,结果表明温度升高,Ⅰ分解加快。又将Ⅰ分别溶于磷酸盐缓冲液、醋酸、盐酸及氢氧化钠等不同pH值的溶液中,于65°贮藏一个月,结果表明,Ⅰ在pH值低的溶液中很不稳定,而在pH值高的溶液中稳定。又将Ⅰ溶于不同浓度的蔗糖溶液中,于65°贮藏三周后,结果表明,蔗糖浓度增大,溶液pH值下降,Ⅰ的分解加速。以山梨醇或甘油代替水作溶剂,能增进Ⅰ的稳定性(山梨醇稍优于甘油),如将Ⅰ溶于5%的山梨醇中,添加10～2%(v/v)的乙醇,则更能增进Ⅰ的稳
This paper reports that the determination and determination of furosemide (I) in aqueous solution by HPLC is more sensitive and accurate than that of the 19th edition of the U.S. Pharmacopeia. Commercially available furosemide solution were stored at room temperature, 45 °, 65 ° and 85 ° four different temperatures, the results show that the temperature increases, Ⅰ decomposition accelerated. In turn, I was dissolved in phosphate buffer, acetic acid, hydrochloric acid and sodium hydroxide at different pH value of the solution, stored at 65 ° for a month, the results show that Ⅰ in the low pH solution is very unstable, Stable at high pH. In turn I dissolved in different concentrations of sucrose solution, stored at 65 ° for three weeks, the results show that the sucrose concentration increases, the solution pH value decreased, Ⅰ decomposition accelerated. Sorbitol or glycerol instead of water as a solvent, can enhance the stability of Ⅰ (sorbitol slightly better than glycerol), such as Ⅰ dissolved in 5% sorbitol, the addition of 10 ~ 2% (v / v) of ethanol, I can enhance the stability of Ⅰ