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目的:探讨促动力药吗丁啉和胆盐结合药铝碳酸镁对胆汁反流性胃炎的疗效及胃内２４小时胆汁的影响。方法:２５例胆汁反流性胃炎患者,经胃内２４小时胆汁监测证实,记录上腹痛、饱胀、恶心、呕吐症状的积分后,予以口服吗丁啉１０ｍｇ,每日餐前１５分钟服用,３次/ｄ,铝碳酸镁０．５ｇ,每日餐后６０分钟服用,３次/ｄ。治疗４周后观察上述症状积分的变化,并复查胃内２４小时胆汁反流情况。结果:治疗２周后４种症状积分较治疗前显著降低(Ｐ＜０．０５)。４周后腹痛、饱胀症状进一步改善,２４小时胃内胆汁反流总时间百分比由治疗前的３０．４±２０．２%降至１５．６±６．６%(Ｐ＜０．０１),反流次数由治疗前的１０４．９±５７．６次降至５０．８±１９．６次。结论:吗丁啉与铝碳酸镁合用能有效缓解胆汁反流性胃炎的症状,降低胃内胆汁反流指标,是治疗胆汁反流性胃炎的有效方案。
OBJECTIVE: To investigate the curative effect of ambroxol and bile salt combination magnesium aluminum carbonate on bile reflux gastritis and the influence of 24 hours bile in the stomach. Methods: Twenty-five patients with bile reflux gastritis were confirmed by 24-hour bile monitoring in the stomach. After recording the points of upper abdominal pain, fullness, nausea and vomiting, they were given 10 mg oxymatrine orally and 15 minutes daily before meals. 3 times / d, magnesium aluminum carbonate 0.5g, daily 60 minutes after meals, 3 times / d. After 4 weeks of treatment, the changes of the above symptom scores were observed and the situation of 24 hours bile reflux in the stomach was reviewed. Results: After 2 weeks of treatment, the scores of 4 kinds of symptoms were significantly lower than those before treatment (P <0.05). After 4 weeks, the symptoms of abdominal pain and bloating further improved. The total time of 24 hours of gastric bile reflux decreased from 30.4 ± 20.2% before treatment to 15.6 ± 6.6% (P <0.01) , The frequency of reflux decreased from 104.9 ± 57.6 before treatment to 50.8 ± 19.6. Conclusion: Combination of domperidone and aluminum magnesium carbonate can effectively relieve the symptoms of bile reflux gastritis and reduce the index of intragastric bile reflux, which is an effective treatment for bile reflux gastritis.