Batroxobin对狗心脏缺血/再灌注损伤中内皮素的影响

• 作 者: 张勇刚 郑直 符民桂 姜志胜 欧和生 夏春芳 王晓红 柴三葆 唐朝枢 刘乃奎
• 机 构: 北京医科大学心血管研究所!北京100083,佳木斯中心医院心内科!佳木斯154007,北京医科大学心血管研究所!北京100083,北京医科大学心血管研究所!北京100083,北京医科大学心血管研究所!
• 出 处: 基础医学与临床
• 发表日期: 2001年01期
• 关键词: Batroxobin I/R损伤 心脏

本工作研究Batroxobin对狗心脏I/R损伤过程中ET水平的影响。将狗左冠状动脉前降支结扎 30min ,恢复血流 90min ,造成I/R模型 ,于缺血前或缺血后 15min静注Batroxobin (1U/kg) ,测定血浆、心肌ET浓度以及血浆CK和LDH活性。结果表明 ,I/R组心肌组织及血浆ET水平明显升高 ,心肌组织明显损伤 ,Batroxobin能够显著降低再灌期血浆及心肌ET水平 ,降低CK及LDH活性 ,减轻心肌组织I/R损伤。

This study was to investigate the effect of Batroxobin on ET level in dog heart during I / R injury. The left anterior descending coronary artery was ligated for 30min and the blood flow was restored for 90min. The I / R model was established. Batroxobin (1U / kg) was injected intravenously 15 min before or after ischemia, and plasma and myocardial ET concentrations and plasma CK and LDH activity. The results showed that the myocardial tissue and plasma ET levels were significantly increased in I / R group and the myocardial tissue was obviously damaged. Batroxobin could significantly decrease the plasma and myocardial ET level, reduce the activity of CK and LDH, and alleviate the myocardial I / R injury.