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Aim: To examine the influence of recurrent therapy with antibiotics (RTA) in i nfancy on children’s somatic factors at 8 y of age. Methods: Subject selection was based on stratified randomized cluster sampling. Altogether 1287 infants wer e potential participants in the follow-up study. Children with ≥6 courses of a ntibiotics (100 children) during their first 18 mo of life and children with no (62%) or ≤2 courses (38%) of antibiotics participated in a clinical examinati on in a case-control setting (100 matched controls) at the age of 8 y. Results: The children with RTA continued to have more infections and had had more course s of antibiotics compared to controls during the follow-up. There was no clinic ally significant difference in the somatic and dental status at the age of 8 bet ween the two groups. The parents of the children with RTA reported significantly more often recurrent infections than the parents of the controls. Conclusions: The childre n with recurrent therapy with antibiotics in early childhood also continue to be prescribed more antibiotics in later childhood when compared to those who recei ved no or few antibiotics in infancy. However, recurrent infections and medicati ons do not seem to have a marked effect on the somatic and dental status of thes e children at 8 y of age.
Aim: To examine the influence of recurrent therapy with antibiotics (RTA) in i nfancy on children’s somatic factors at 8 y of age. Methods: Subject selection was based on stratified randomized cluster sampling. Altogether 1287 infants wer e potential participants in the follow- up study. Children with ≥6 courses of a ntibiotics (100 children) during their first 18 months of life and children with no (62%) or ≤2 courses (38%) of antibiotics participated in a clinical examinati on in a case- Results: The children with RTA continued to have more infections and had had more course s of antibiotics compared to controls during the follow-up. There was no clinic ally significant difference in the somatic and dental status at the age of 8 bet ween the two groups. The parents of the children with RTA reported significantly more often recurrent infections than the parents of the controls. Conclusions: The child of n with recurrent therapy wi th antibiotics in early childhood also continue to be clear more antibiotics in later childhood when compared to those who who ve ve no or few antibiotics in infancy. However, recurrent infections and medicati ons do not seem to have a marked effect on the somatic and dental status of thes e children at 8 y of age.