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【目的】 探讨巨细胞病毒 (CMV)先天性、围生期和生后感染的临床特点。 【方法】 对 10 0例活动性CMV感染患儿的临床观察指标进行方差分析及两两比较。 【结果】 发现先天组孕周和出生体重均数明显低于围生组与生后感染组 ,而WBC、TBIL和γ -GT均数明显高于后两组。提示先天性CMV感染常常导致胎儿宫内发育迟缓 ,新生儿出生体重过轻或早产 ,明显加重新生儿黄疸和胆汁淤积。外周血白细胞明显升高 ,推测宿主白细胞获得CMV感染可能。此外 ,先天组合并畸形和死亡率明显高于后两组。【结论】 先天性CMV感染的危害最大 ,重点是抓好先天性CMV感染的防治
【Objective】 To investigate the clinical features of cytomegalovirus (CMV) congenital, perinatal and postnatal infections. 【Methods】 One hundred and twenty cases of active CMV infection in children with clinical observation of variance analysis and pairwise comparison. 【Results】 The mean gestational age and birth weight of the congenital group were significantly lower than those of the perinatal group and the postnatal group, while the mean WBC, TBIL and γ-GT were significantly higher than the latter two groups. Prompt congenital CMV infection often leads to intrauterine growth retardation, neonatal birth weight or premature birth, significantly aggravate neonatal jaundice and cholestasis. Peripheral blood leukocytes significantly increased, presumably the host white blood cells may CMV infection. In addition, congenital malformations and mortality were significantly higher than the latter two groups. 【Conclusions】 Congenital CMV infection is the most harmful, and the key point is prevention and control of congenital CMV infection