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目的探讨腹腔注射卡铂治疗中晚期卵巢癌的临床效果。方法应用腹腔注射卡铂联合静脉应用紫杉醇化疗方案治疗40例中晚期卵巢癌患者,观察其疗效和不良反应。采用WHO推荐的评价实体瘤客观指标评定疗效,分为完全缓解(CR)、部分缓解(PR)、稳定(NC)和进展(PD),以CR和PR为有效。结果 40例中CR 9例,PR 25例,NC 5例,PD 1例,有效率85%,主要不良反应为骨髓抑制、脱发、恶心、呕吐。结论腹腔注射卡铂联合静脉紫杉醇化疗治疗卵巢癌疗效好,不良反应少。
Objective To investigate the clinical effect of intraperitoneal injection of carboplatin in the treatment of advanced ovarian cancer. Methods 40 patients with advanced ovarian cancer were treated with paclitaxel chemotherapy by intraperitoneal injection of carboplatin combined with intravenous injection. The curative effect and adverse reactions were observed. Objective To evaluate the curative effect of solid tumor which is recommended by WHO and divided into complete remission (CR), partial remission (PR), stable (NC) and progress (PD), and CR and PR as effective. Results Among 40 cases, 9 were CR, 25 were PR, 5 were NC and 1 was PD. The effective rate was 85%. The main adverse reactions were myelosuppression, hair loss, nausea and vomiting. Conclusion Intraperitoneal injection of carboplatin combined with intravenous paclitaxel chemotherapy for ovarian cancer with good efficacy and few adverse reactions.