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为研究葡萄糖、精氨酸对新生大鼠胰岛β细胞群的影响，选用Ｗｉｓｔａｒ新生大鼠，于出生后第２日起腹腔注射葡萄糖加精氨酸，共６ 天。分别于出生后第１０、２０ 天剖腹取胰腺，进行ＨＥ及胰岛素免疫组织化学（ＰＡＰ）染色，并应用图像分析系统测量胰岛及β细胞群的直径。结果：实验组和对照组大鼠生后２０ 天胰岛直径较其第１０ 天的显著缩小，对照组β细胞群的直径从第１０ 天到２０ 天，也表现为明显缩小；然而，实验组β细胞群直径却表现为有意义的增加。提示葡萄糖加精氨酸可促进β细胞群的发育
In order to study the effects of glucose and arginine on the islet β cell population of neonatal rats, Wistar neonatal rats were used to inoculate glucose and arginine intraperitoneally on the second day after birth for 6 days. Pancreatic glands were harvested on the 10th and 20th day after birth for HE and insulin immunohistochemistry (PAP) staining. The diameter of islet and β-cell population was measured by image analysis system. Results: The diameter of pancreatic islets in experimental group and control group decreased significantly on the 20th day after birth compared with that on the 10th day. The diameter of the β cell population in the control group decreased significantly from day 10 to day 20; however, in experimental group β Cell population diameter showed a significant increase. Tip glucose and arginine can promote the development of β cell population