香丹注射液与5种输液配伍的微粒探讨

• 作 者: 冯璐璐 任广军
• 机 构: 平顶山市第一人民医院,河南平顶山市叶县人民医院 河南平顶山467000
• 出 处: 中国药师
• 发表日期: 2007年07期
• 关键词: 香丹注射液 配伍 不溶性微粒

目的:探讨香丹注射液与不同输液配伍时不溶性微粒的变化,选择出最适宜与香丹注射液配伍的输液。方法:分别将香丹注射液用0.9%氯化钠注射液(0.9%NS)、5%葡萄糖注射液(5%GS)、10%葡萄糖注射液(10%GS)、5%葡萄糖氯化钠注射液(5%GNS)、复方氯化钠注射液(RS)稀释成临床常用浓度,测定微粒数,选择出最适宜与香丹注射液配伍的输液。结果:香丹注射液与五种输液配伍后,不同直径的不溶性微粒均有所增加;与10%GS、RS配伍后≥10μm的微粒数均超标;与0.9%NS、5%GS、5%GNS配伍后,不溶性微粒数均符合规定。结论:香丹注射液配液时,应选择0.9%NS、5%GS、5%GNS为宜。

Objective: To investigate the change of insoluble particles when Xiangdan injection and different infusion compatibility, select the most suitable infusion with Xiangdan injection compatibility. Methods: Xiangdan injection was treated with 0.9% sodium chloride injection (0.9% NS), 5% glucose injection (5% GS), 10% glucose injection (10% GS), 5% Injection (5% GNS), compound sodium chloride injection (RS) diluted to clinical common concentrations, the determination of the number of particles, select the most appropriate and Xiangdan injection compatible infusion. Results: The compatibility of Xiangdan injection and five kinds of infusions increased with the increase of insoluble particulates with different diameters. The number of particulates with the size of ≥10μm after 10% GS and RS combination exceeded the standard of 0.9% NS, 5% GS, 5% GNS compatibility, the number of insoluble particles are in line with the provisions. Conclusion: Xiangdan injection with dosing should choose 0.9% NS, 5% GS, 5% GNS appropriate.