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目的探讨老年慢性心力衰竭(CHF)患者血清介素-8(IL-8)的变化及福辛普利对其影响。方法采用双抗夹心ELISA法检测40例老年CHF患者及20例健康者血清IL-8水平。并将老年CHF患者分为常规治疗组(19例)和常规治疗+福辛普利治疗组(福辛利组21例)共观察3周。结果老年CHF患者血清IL-8水平显著高于对照组(<0.01),且与左室射血分数(LVEF)呈负相关(=-0.45,<0.05);经3周治疗后福辛普利组患者IL-8水平明显降低(<0.05),且伴有心率明显下降(<0.05)和LVEF明显增高(<0.05)。结论老年CHF患者存在IL-8水平明显增高,并与左室收缩功能呈负相关,福辛普利可降低血清IL-8水平有益于老年CHF患者心功能改善。
Objective To investigate the changes of serum interleukin-8 (IL-8) in elderly patients with chronic heart failure (CHF) and the effect of fosinopril on it. Methods Serum levels of IL-8 in 40 elderly CHF patients and 20 healthy controls were measured by double-antibody sandwich ELISA. The elderly CHF patients were divided into routine treatment group (n = 19) and conventional treatment + fosinopril treatment group (foxingli group, 21 cases) for 3 weeks. Results Serum levels of IL-8 in elderly patients with CHF were significantly higher than those in the control group (<0.01), and negatively correlated with left ventricular ejection fraction (LVEF) (= -0.45, <0.05). After 3 weeks of treatment, The levels of IL-8 in patients were significantly lower (<0.05), accompanied by a significant decrease in heart rate (<0.05) and LVEF (<0.05). Conclusion There is a significant increase of IL-8 level in elderly CHF patients and a negative correlation with left ventricular systolic function. Fosinopril can reduce the serum level of IL-8, which is beneficial to the improvement of cardiac function in elderly CHF patients.