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随着科学技术的进步和检测分析手段的完善，发现过去认为安全的一些纯化学合成品在用作食品添加剂时有致癌或潜在致癌的可能性，如用于肉类着色和防腐的NaNO2在消化系统中可与脯氨酸形成强致癌剂N-亚硝胺类，食品防腐剂和抗氧剂BHA（丁基羟基茵香醚）在动物实验中证明有致癌性
With the progress of science and technology and the improvement of testing and analysis methods, some purified chemical syntheses which were considered safe in the past were found to be carcinogenic or potentially carcinogenic when used as food additives, such as NaNO2 for meat coloring and preservation System can form strong carcinogens N-nitrosamines with proline, food preservatives and antioxidants BHA (butyl hydroxy Yin Xiang ether) in animal experiments proved to be carcinogenic