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为观察突变型P53 基因产物P53 蛋白在鼻咽低分化鳞癌的表达情况 ,探讨该基因突变与桂西南地区鼻咽癌颈转移的关系 ,采用S -P免疫组化法检测 5 0例鼻咽癌标本的P53 蛋白 ,对其结果行统计学卡方 ( χ2 )检验分析。结果鼻咽癌P53总阳性率为 5 8% ( 2 9/ 5 0 ) ,有颈淋巴结转移者P53 阳性率 73 .5 % ( 2 5 / 3 4 ) ,无转移者为 2 5 % ( 4 / 16) ,两者差异有高度显著性 (P <0 .0 1) )。提示P53 蛋白过度表达与鼻咽癌颈淋巴结转移有关
To observe the expression of P53 protein in poorly differentiated squamous cell carcinoma of the nasopharynx, and to explore the relationship between the gene mutation and cervical metastasis of nasopharyngeal carcinoma in southwestern Guangxi Province. Fifty nasopharyngeal samples were detected by S-P immunohistochemistry Cancer specimens of P53 protein, the results of statistical chi-square (χ2) test analysis. Results The positive rate of P53 in nasopharyngeal carcinoma was 58% (29/50), the positive rate of P53 was 73.5% (25/34) in patients with cervical lymph node metastasis, and 25% (4 / 16), the difference was highly significant (P <0.01)). Tip P53 protein overexpression and cervical lymph node metastasis