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Objective To investigate the clinical effect of different types of skin flap transplantation in repairing forefoot lesion.Methods From January 2016 to June 2019, 62 patients with forefoot damage were selected and their clinical data were retrospectively analyzed. All the selected patients received skin flap transplantation and repair, of which 26 patients received free myocutaneous flap transplantation and repair, and were treated as group A. The other 36 patients underwent retrograde foot flap transplantation and repair. They were taken as group B, and the clinical treatment methods and curative effects were summarized. Results Among the 26 patients in group A, the skin flaps of 21 patients survived completely, while those of the other 5 patients showed partial necrosis at the edge of the skin flaps. They were treated with free skin grafting and healed after regular dressing change. All the skin flaps survived. Follow-up for at least 6 months showed that 11 patients had mild claudication and skin flap sensation was slightly poor. Among the 36 patients in group B, only 2 cases suffered from distal partial necrosis after the operation, which was caused by large tension after dorsum pedis flap transplantation. After systematic treatment and regular dressing change by doctors, the flaps of 2 patients healed. In addition, venous reflux disorder occurred in 3 patients with medial saphenous nerve nutrient vessel flap of the foot, which was related to swelling factors. The flaps of other patients survived, healed well and did not show infection symptoms. Conclusion According to the actual condition of patients with forefoot damage, the flap repair method is formulated, which has good short-term and long-term therapeutic effects and plays an important role in repairing forefoot damage.