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目的观察纳洛酮联合门冬氨酸鸟氨酸治疗肝性脑病的临床疗效。方法将40例肝性脑病患者随机分为观察组和对照组,每组各20例。对照组给予常规综合治疗,观察组在此基础上应用纳洛酮联合门冬氨酸鸟氨酸治疗,疗程均为7d。观察两组患者的总有效率、神智转清醒时间、血氨浓度以及肝功能(AST、TBiL)、NCT和DST改善情况。结果观察组的总有效率、神智转清醒时间、血氨浓度以、肝功能(AST、ALT)、NCT和DST较对照组明显改善(P<0.05)。结论在综合治疗基础上,纳洛酮联合门冬氨酸鸟氨酸治疗肝性脑病疗效显著,值得临床推广。
Objective To observe the clinical efficacy of naloxone combined with aspartate ornithine in the treatment of hepatic encephalopathy. Methods 40 cases of hepatic encephalopathy were randomly divided into observation group and control group, 20 cases in each group. Control group was given conventional comprehensive treatment, the observation group on this basis, the application of naloxone combined with aspartate ornithine treatment, treatment were 7d. The total effective rate of the two groups were observed, the time of consciousness to wake up, serum ammonia concentration and the improvement of liver function (AST, TBiL), NCT and DST. Results The total effective rate of the observation group, the time of recuperation, the serum ammonia concentration, liver function (AST, ALT), NCT and DST were significantly improved compared with the control group (P <0.05). Conclusion On the basis of comprehensive treatment, naloxone combined with aspartate ornithine has a significant therapeutic effect on hepatic encephalopathy and is worthy of clinical promotion.