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血管内皮损伤是动脉粥样硬化(atherosclerosis,AS)发生的始动环节,内皮功能障碍在冠状动脉粥样硬化性心脏病(Coronary Heart Disease)的发病机制中起重要作用。氧化低密度脂蛋白(ox-LDL)是引起内皮损伤的关键因素之一,血管内皮损伤能促进血管内皮的氧化和炎症。ox-LDL可通过激活转录因子NF-κB,诱导血管内皮细胞及单核-巨噬细胞表达粘附分子、趋化性细胞因子、促炎因子及其它炎症反应的中介物。通脉汤是治疗冠心病的中药复方,是孙明教授经过多年临床实践总结出来的经验方,并从
Vascular endothelial injury is the first step in the development of atherosclerosis (AS). Endothelial dysfunction plays an important role in the pathogenesis of Coronary Heart Disease. Oxidized low-density lipoprotein (ox-LDL) is one of the key factors that lead to endothelial injury, vascular endothelial injury can promote endothelial oxidation and inflammation. Ox-LDL can induce the expression of adhesion molecules, chemotactic cytokines, proinflammatory cytokines and other inflammatory mediators in vascular endothelial cells and monocyte-macrophages by activating the transcription factor NF-κB. Tongmai Tang is the traditional Chinese medicine treatment of coronary heart disease compound, Professor Sun Ming after many years of clinical practice summed up the experience of prescription, and from