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目的：探讨胃十二指肠疾病患者临床幽门螺杆菌（ＨＰ）感染率，对１７３１例胃十二指肠疾病患者进行胃镜活检ＨＰ检查。方法：采用尿素酶、氧化酶和涂片显微镜检测胃粘膜标本中的ＨＰ。结果：十二指肠溃疡ＨＰ检出率最高（７５．８１％），胆汁反流性胃炎最低（４２．１１％），胃癌检出率达４６％，差异显著（Ｐ＜０．００５）。男性ＨＰ检出率显著高于女性（Ｐ＜０．００５）。结论：ＨＰ不仅与胃十二指肠炎和溃疡有密切关系，而且与胃癌也有一定关系。
Objective: To investigate the prevalence of Helicobacter pylori (HP) infection in patients with gastroduodenal disease and gastroscopic biopsy (HP) examination of 1731 patients with gastroduodenal diseases. Methods: HP in gastric mucosa was detected by urease, oxidase and smear microscopy. Results: The detection rate of duodenal ulcer was the highest (75.81%), the lowest was bile reflux gastritis (42.11%), and the detection rate of gastric cancer was 46% (P <0.005). The detection rate of male HP was significantly higher than that of female (P <0.005). Conclusion: HP is not only closely related to gastroduodenitis and ulcer, but also to gastric cancer.