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目的探讨血浆神经肽Y在先兆子痫发生及发展中的意义。方法采用放射免疫分析法测定20例先兆子痫患者(先兆子痫组)及20例正常妊娠妇女分娩前血浆神经肽Y水平及分娩3～5d后血浆神经肽Y水平。结果分娩前先兆子痫组血浆神经肽Y水平(206.98±45.71)ng/L明显高于正常妊娠组(84.24±55.39)ng/L,差异有统计学意义(P<0.01);先兆子痫组分娩后神经肽Y水平(105.15±32.21)ng/L明显下降,与分娩前比较差异有统计学意义(P<0.O1)。先兆子痫组分娩前神经肽Y水平与收缩压及平均动脉压均呈正相关(r分别为0.497、0.470,P均<0.05),分娩后血浆神经肽Y水平与收缩压及平均动脉压均无相关性(r分别为-0.040、-0.177,P均>0.05)。结论先兆子痫患者血浆神经肽Y水平明显升高,且分娩前的神经肽Y水平与收缩压及平均动脉压呈正相关,神经肽Y在先兆子痫的发生及发展中可能发挥了重要的作用。
Objective To investigate the significance of plasma neuropeptide Y in the development and progression of preeclampsia. Methods Radioimmunoassay was used to determine plasma neuropeptide Y levels and plasma neuropeptide Y levels in 20 preeclampsia patients (preeclampsia group) and 20 normal pregnant women before delivery. Results The level of neuropeptide Y in preeclampsia group (206.98 ± 45.71) ng / L before delivery was significantly higher than that in normal pregnancy group (84.24 ± 55.39) ng / L, the difference was statistically significant (P <0.01) Neuropeptide Y levels (105.15 ± 32.21) ng / L after delivery were significantly lower than those before delivery (P <0.O1). Pre-eclamptic group neuropeptide Y levels before delivery and systolic blood pressure and mean arterial pressure were positively correlated (r = 0.497,0.470, P <0.05), postpartum plasma neuropeptide Y levels and systolic blood pressure and mean arterial pressure were Correlation (r = -0.040, -0.177, P> 0.05). Conclusions The level of plasma neuropeptide Y in preeclampsia patients is significantly increased, and the level of NPY before delivery is positively correlated with systolic pressure and mean arterial pressure. Neuropeptide Y may play an important role in the development of preeclampsia .