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前列腺素E系列具有免疫抑制特性。Misoprostol为前列腺素E_1的衍生物。作者设计了一个前瞻性,双盲、安慰剂对照试验以观察该药对肾移植后肾功能和移植排异方面的影响。治疗组38例在移植术后的头12周中每日四次口服misoprostol 200ug。对照组则服安慰剂。两组同时都还采用了环孢素加强的松的标准免疫抑制疗法。每四周观察一次直至停药。结果,治疗组的肾功能有显著改善,而且,急性排异的发生率有显著减少。治疗组环孢素的血药浓度偏高,并发感染的例数偏少,但统计学上无显著
Prostaglandin E series has immunosuppressive properties. Misoprostol is a derivative of prostaglandin E_1. The authors designed a prospective, double-blind, placebo-controlled trial to examine the effects of the drug on renal function and transplant rejection after kidney transplantation. Thirty-eight patients in the treatment group received 200 μg of misoprostol orally four times daily during the first 12 weeks after transplantation. The control group was given placebo. Both groups also used standard immunosuppressive therapy with ciclosporin-boosted pine. Observed every four weeks until withdrawal. As a result, the renal function of the treatment group was significantly improved, and the incidence of acute rejection was significantly reduced. The treatment group cyclosporine blood concentration is high, the number of concurrent infections less, but no statistically significant