论文部分内容阅读
研究背景及临床问题:高胆固醇血症是公认的卒中危险因素。叶酸可改善内皮功能紊乱和硝酸盐耐受性,并且能改善动脉粥样硬化的病理学特征;同时具有潜在的降低同型半胱氨酸作用,以及直接抗氧化剂和抗血栓形成作用。HOPE-2(Heart Outcomes Prevention Evaluation 2)研究结果显示,相比于较低高胆固醇(TC)水平的患者,叶酸治疗有降低高TC水平患者卒中风险的趋势。但既往研究结果缺少随机对照试验的验证。
Background and clinical issues: Hypercholesterolemia is a recognized risk factor for stroke. Folic acid can improve endothelial dysfunction and nitrate tolerance, and can improve the pathological features of atherosclerosis; at the same time, it has the potential to reduce homocysteine and direct anti-oxidant and antithrombotic effects. Results of the HOPE-2 (Heart Outcomes Prevention Evaluation 2) study showed that folic acid therapy had a tendency to reduce the risk of stroke in patients with high TC levels compared with patients with lower levels of high cholesterol (TC). However, previous studies lacked the validation of randomized controlled trials.