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Rho激酶,又称Rho相关的卷曲蛋白激酶,是一类丝氨酸/苏氨酸蛋白激酶,被发现为小G蛋白Rho的下游作用底物。由于Rho激酶活性涉及神经细胞的功能,而且越来越多的研究表明抑制Rho激酶的活性在数种神经退行性疾病包括帕金森病、阿尔茨海默病、亨廷顿病、多发性硬化症,和肌萎缩性侧索硬化症等的实验模式中都有明显的效果。因此,Rho激酶已成为针对治疗神经性退化性疾病的一个热门标靶蛋白。本文探讨Rho激酶抑制剂在神经退化性疾病上的应用及发展,使神经退行性疾病能进一步提升治疗和在应用上的水平。
Rho kinase, also known as Rho-related Frizzled Protein Kinase, is a serine / threonine protein kinase that was found to be a downstream substrate for the small G protein Rho. Since Rho kinase activity is involved in the function of nerve cells, and more and more studies have shown that inhibiting Rho kinase activity in several neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, multiple sclerosis, and Amyotrophic lateral sclerosis and other experimental models have obvious effects. Therefore, Rho kinase has become a hot target protein for the treatment of neurodegenerative diseases. This article discusses the Rho kinase inhibitors in the application of neurodegenerative diseases and development, so that neurodegenerative diseases can further enhance the level of treatment and application.