论文部分内容阅读
目的探讨3HRZL/9HR方案治疗结核性脑膜炎的临床疗效。方法选取东台市人民医院2011—2015年收治的结核性脑膜炎患者35例,根据随机数字表法分为改良组(n=18)和对照组(n=17)。患者入院后均给予常规对症支持治疗。对照组患者采用传统3HRZS/9HR治疗方案,改良组患者采用3HRZL/9HR治疗方案,两组患者均持续治疗3个月。比较两组患者的临床疗效及治疗前后脑脊液相关指标(细胞计数、蛋白定量、氯化物和葡萄糖定量)。观察两组患者毒副反应发生情况。结果改良组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者细胞计数、蛋白定量、氯化物及葡萄糖定量比较,差异无统计学意义(P>0.05);治疗后,改良组患者细胞计数、蛋白定量低于对照组,氯化物、葡萄糖定量高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用3HRZL/9HR方案治疗结核性脑膜炎的临床疗效确切,可明显改善脑脊液相关指标,促进疾病康复。
Objective To investigate the clinical effect of 3HRZL / 9HR regimen in the treatment of tuberculous meningitis. Methods Thirty-five patients with tuberculous meningitis admitted from 2011 to 2015 in Dongtai People’s Hospital were divided into three groups according to random number table: modified group (n = 18) and control group (n = 17). After admission, patients were given conventional symptomatic and supportive treatment. The control group of patients with conventional 3HRZS / 9HR treatment, the modified group of patients with 3HRZL / 9HR treatment, both groups were treated for 3 months. The clinical efficacy and CSF-related indicators (cell count, protein quantitation, chloride and glucose quantitation) before and after treatment were compared between the two groups. Observation of two groups of patients with side effects. Results The clinical efficacy of the improved group was better than that of the control group (P <0.05). Before treatment, there was no significant difference in the cell count, protein quantification, chloride and glucose between the two groups (P> 0.05). After treatment, the cell counts and the protein quantitation in the modified group were lower than those in the control group, chloride and glucose Quantitative higher than the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The clinical efficacy of 3HRZL / 9HR regimen in the treatment of tuberculous meningitis is accurate, which can significantly improve cerebrospinal fluid related indicators and promote the recovery of the disease.