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以PCl5和NH4Cl为原料,利用一锅法制备了聚二氯膦腈,通过两步亲核取代反应,分别以甘氨酸乙酯和对羟基苯甲酸甲酯为亲核试剂,合成了混合取代可生物降解聚[(对羟基苯甲酸甲酯/甘氨酸乙酯)膦腈].用核磁共振波谱及红外光谱等对产物结构进行了表征.研究了甘氨酸乙酯和对羟基苯甲酸甲酯的比例及外界环境对所制备的聚膦腈降解性能的影响,并进行了体外降解实验.研究结果表明,通过改变甘氨酸乙酯和对羟基苯甲酸甲酯的比例,可获得一种降解速率可调节的生物降解膦腈聚合物.
Using PCl5 and NH4Cl as raw materials, a one-pot method was used to prepare poly-dichlorophosphazene. Two steps of nucleophilic substitution reaction, glycine ethyl ester and methyl paraben respectively, Degradation of poly [(p-hydroxybenzoate / glycine ethyl ester) phosphazene] .The structure of the product was characterized by NMR and IR spectra.The proportion of glycine ethyl ester and methyl paraben and the external Environment on the prepared polyphosphazene degradation performance and in vitro degradation experiments.The results show that by changing the ratio of glycine ethyl ester and methyl paraben can be obtained a biodegradable rate of degradation can be adjusted Phosphazene polymer.