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目的:探讨早期无创正压通气治疗慢性阻塞性肺疾病(COPD)急性加重期合并急性肺动脉栓塞的临床效果。方法:选择2014年8月至2015年8月东莞市第三人民医院收治的198例COPD急性加重期合并急性肺动脉栓塞患者,并从中随机筛选出50例作为研究对象,分为观察组和对照组,每组各25例,对照组给予持续低流量吸氧治疗,观察组采用无创正压通气方法治疗。比较两组患者治疗前后血气变化、插管率、生命体征恢复平稳时间、住院时间等,并记录不良反应及并发症发生情况。结果:与对照组比较,观察组患者PaO_2、pH值显著升高,PaCO_2显著降低,观察组所需生命征恢复平稳时间、住院时间相对较短(P<0.05);两组插管率比较,差异无统计学意义(P>0.05),两组均无严重不良反应。结论:早期无创正压通气治疗慢性阻塞性肺疾病急性加重期合并急性肺动脉栓塞临床疗效显著,适合推广和普及。
Objective: To investigate the clinical effect of early noninvasive positive pressure ventilation in the treatment of acute pulmonary embolism with acute exacerbation of chronic obstructive pulmonary disease (COPD). METHODS: A total of 198 patients with acute exacerbation of COPD admitted to the Third People’s Hospital of Dongguan from August 2014 to August 2015 were enrolled in the study. Fifty patients were randomly selected as the study subjects and divided into observation group and control group , 25 cases in each group. The control group was given continuous low-flow oxygen therapy. The observation group was treated with noninvasive positive pressure ventilation. The changes of blood gas, intubation rate, the recovery time of vital signs, hospitalization time and so on were compared between the two groups before and after treatment. The incidence of adverse reactions and complication were recorded. Results: Compared with the control group, PaO_2, pH value and PaCO_2 in observation group were significantly lower than those in control group. The recovery time of vital signs and hospital stay in observation group were relatively shorter (P <0.05) The difference was not statistically significant (P> 0.05), no serious adverse reactions in both groups. Conclusion: The early non-invasive positive pressure ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease with acute pulmonary embolism has significant clinical efficacy, suitable for the promotion and popularization.