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目的:研究学龄儿童及青少年血清促甲状腺激素(TSH)水平和血压的关系。方法:采用随机整群抽样的方法对安徽蚌埠地区880名7～18岁学龄儿童及青少年进行横断面调查,填写问卷,测量血压、身高、体重,空腹抽血测血清TSH,TSH异常者进一步测血清游离三碘甲状腺游氨酸(FT3)、游离甲状腺素(FT4)。分析不同甲状腺功能状态组的收缩压(SBP)和舒张压(DBP)的特征,了解这一人群TSH与血压的关联。结果:①血清TSH与SBP和DBP均存在正相关关系,在校正了年龄、性别、体质指数(BMI)的影响后,血清TSH与SBP和DBP的正向相关性依然存在;按性别分层发现,这种正相关关系在男性中尤其明显(相关系数r分别为0.1155、0.1302,P分别为0.007、0.002);②亚临床甲状腺功能减退(亚甲减)组的SBP和DBP水平高于甲状腺功能正常组,分别增加2.6mmHg和2.2mmHg。结论:随着血清TSH的增加,SBP和DBP有所升高,学龄儿童及青少年亚甲减组血压高于甲功正常组,此研究为儿童及青少年高血压人群中的重点筛查和亚临床甲减早期干预治疗提供了临床依据。
Objective: To study the relationship between serum thyroid stimulating hormone (TSH) and blood pressure in school-age children and adolescents. Methods: A total of 880 school-age children aged 7-18 years and adolescents in Bengbu, Anhui Province were investigated by cross-sectional random sampling methods. Questionnaires were taken and blood pressure, height, weight, fasting blood and serum TSH and TSH were measured. Serum free triiodothyronine (FT3), free thyroxine (FT4). The characteristics of systolic blood pressure (SBP) and diastolic blood pressure (DBP) in different groups of thyroid function were analyzed to find out the correlation between TSH and blood pressure in this group. Results: ① There was a positive correlation between serum TSH and SBP and DBP. After adjusting for age, gender and body mass index (BMI), there was still a positive correlation between serum TSH and SBP and DBP; by stratified by sex (R = 0.1155,0.1302, P = 0.007,0.002, respectively); ② The levels of SBP and DBP in subclinical hypothyroidism (hypothyroidism) group were higher than those in thyroid function The normal group, respectively, an increase of 2.6mmHg and 2.2mmHg. Conclusion: With the increase of serum TSH, the SBP and DBP levels are elevated. The blood pressure of hypothyroidism in school-age children and adolescents is higher than that of normal thyroid function. This study is a key screening and subclinical study in children and adolescents with hypertension. Hypothyroidism early treatment provides a clinical basis.