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早在一个多世纪前已知苯是一种严重的骨髓毒物。慢性苯中毒被描述为再生障碍性贫血或再生不良性贫血。其临床特征是或呈慢性进行性再生不良性贫血,或呈多发性贫血、坏疽性咽峡炎、败血症等迅速致命的出血性白细胞缺乏症。曾经多次见到进行性再生不良性贫血,由于严重的粒细胞减少症和血小板减少症而突然恶化,最后导致出血、败血症而死亡。 1928年Delore和Borgomans描述了第一例苯白血病病例,是一位工人患急性白血病。他接触苯之严重,以致其同伴们无一能忍受二个月以上的工作而不患病者。其后不久,发表
As early as more than a century ago, benzene was known to be a serious bone marrow poison. Chronic benzene poisoning is described as aplastic anemia or aplastic anemia. Its clinical features are either chronic progressive anaplastic anemia, or multiple anemia, gangrenous angina, sepsis and other rapidly fatal hemorrhagic leukocytosis. Have repeatedly seen progressive recurrent anaerobic anemia, due to severe agranulocytosis and thrombocytopenia and sudden deterioration, leading to bleeding, sepsis and death. Delore and Borgomans in 1928 described the first case of leukemia, a worker with acute leukemia. He was exposed to benzene so severely that none of his companions could endure work more than two months without suffering from the disease. Shortly afterwards, published