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目的对外放疗联合252锎中子近距离后装腔内照射治疗宫颈癌远期疗效进行观察分析。方法 80例宫颈癌患者,随机分为对照组和观察组,各40例。对照组实施外放疗联合192Ir近距离后装腔内照射治疗,观察组实施外放疗联合252锎中子近距离后装腔内照射治疗,对患者的临床治疗效果进行为期5年的随访。结果观察组患者1年生存率为97.5%,2年生存率为90.0%,3年生存率为87.5%,4年生存率为72.5%,5年生存率为70.0%。对照组患者的1年生存率为87.5%,2年生存率为72.5%,3年生存率为67.5%,4年生存率为50.0%,5年生存率为45.0%。观察组与对照组患者的2、3、4、5年生存率比较,差异具有统计学意义(P<0.05)。观察组与对照组并发症发生情况比较,差异无统计学意义(P>0.05)。结论在宫颈癌治疗中,外放疗联合252锎中子近距离后装腔内照射治疗,患者的承受力较好,在治疗的过程中患者产生的并发症较少,可以提高宫颈癌放疗远期治疗效果,值得临床推广应用。
Objective To observe and analyze the long-term curative effect of external radiotherapy combined with 252 锎 neutron brachytherapy in the treatment of cervical cancer. Methods 80 patients with cervical cancer were randomly divided into control group and observation group, 40 cases in each. In the control group, external beam irradiation combined with 192Ir brachytherapy was performed. In the observation group, external beam radiotherapy combined with 252 锎 neutron brachytherapy was performed. The clinical effect of the patients was followed up for 5 years. Results The 1-year survival rate was 97.5%, the 2-year survival rate was 90.0%, the 3-year survival rate was 87.5%, the 4-year survival rate was 72.5%, and the 5-year survival rate was 70.0%. The 1-year survival rate of the control group was 87.5%, the 2-year survival rate was 72.5%, the 3-year survival rate was 67.5%, the 4-year survival rate was 50.0%, and the 5-year survival rate was 45.0%. The difference of 2, 3, 4, 5-year survival rate between the observation group and the control group was statistically significant (P <0.05). There was no significant difference in the incidence of complications between observation group and control group (P> 0.05). Conclusion In the treatment of cervical cancer, radiotherapy combined with 252 锎 neutron posterior closed intracavitary irradiation treatment, the patient’s tolerance is better, in the course of treatment of patients with fewer complications, can improve the long-term radiotherapy of cervical cancer Therapeutic effect, it is worth clinical application.