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For further clarifying the central mechanism for penile erec-tion, the effect of metheylene blue on oxytocin-induced penile erec-tion was studied in rabbits. The basal pressure of copora cavernosa(PCC) was (2.5± 1.8) mmHg. Oxytocin was injected intracere-broventricularly at doses of 2 ug, 5 ug or 10 ug. The PCC was ele-vated periodically and rhythmically at 5 ug or 10 ug dose levels withmaximal PCC of (4.5 ±3.5) mmHg and (31 ±10) mmHg, re-spectively. Oxytocin-induced penile erection was prevented bymethylene blue, an inhibitor of guanylate cyclase, injected intra-coporally. Data support the view that NO plays a key role in penileerection. (Chin J Androl 2001; 2: 92-4)
For further clarifying the central mechanism for penile erec-tion, the effect of metheylene blue on oxytocin-induced penile ereculation was studied in rabbits. The basal pressure of copora cavernosa (PCC) was (2.5 ± 1.8) mmHg. Oxytocin was injected The PCC was ele-vated periodically and rhythmically at 5 ug or 10 ug dose levels with maximal PCC of (4.5 ± 3.5) mmHg and (31 ± 10) mmHg, rectally-broventricularly at doses of 2 ug, 5 ug or 10 ug. -spectively. Oxytocin-induced penile erection was prevented by methylene blue, an inhibitor of guanylate cyclase, injected intra-coporally. Data support the view that NO plays a key role in penileection. (Chin J Androl 2001; 2: 92-4)