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目的观察中西医结合治疗糖尿病肾病的临床疗效。方法选取2007年4月～2011年6月在我院住院或门诊的70例糖尿病肾病患者,随机分为治疗组和对照组,对照组35例采用常规西医降糖药物治疗,治疗组35例在常规西医治疗的基础上加用益气养阴活血的中药治疗。两组疗程均为3个月。观察两组治疗前后空腹血糖(FBG)、糖化血红蛋白(HbA1c)、尿微量白蛋白(UmAlb)、血清肌酐(Scr)、内生肌酐清除率(Ccr)及24h尿蛋白定量、尿微量白蛋白排泄率(UAER)、血β2微球蛋白(β2-Mg)的变化情况。结果治疗组总有效率为88.75%;对照组总有效率为62.86%。治疗组疗效优于对照组(P<0.01);两组治疗后UAER、Scr、UmAlb、Ccr较治疗前有明显下降,组间比较差异有统计学意义(P<0.05)。两组治疗前后FBG、HbAlc无明显变化(P>0.05);治疗后治疗组的血β2-Mg较治疗前有明显下降(P<0.05),对照组β2-Mg治疗前后无明显变化。结论中西医结合治疗糖尿病肾病疗效显著,可以减轻肾损害、延缓肾功能恶化、保护肾脏,从而减缓糖尿病肾病的病程进展。
Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of diabetic nephropathy. Methods Seventy patients with diabetic nephropathy hospitalized or outpatient in our hospital from April 2007 to June 2011 were randomly divided into treatment group and control group. 35 patients in control group were treated with conventional western medicine, and 35 in treatment group On the basis of conventional Western medicine plus traditional Chinese medicine treatment of nourishing yin and activating blood circulation. Two groups of treatment are 3 months. The levels of fasting blood glucose (FBG), HbA1c, UmAlb, Scr, Ccr and 24h urinary protein and urine microalbumin excretion were observed before and after treatment. Rate (UAER), blood β2 microglobulin (β2-Mg) changes. Results The total effective rate was 88.75% in the treatment group and 62.86% in the control group. Treatment group than the control group (P <0.01); there is significantly decreased after treatment UAER, Scr, UmAlb, Ccr than before treatment, comparing differences between groups was statistically significant (P <0.05). Before and after treatment FBG, HbAlc was no significant change (P> 0.05); significantly decreased (P <0.05) β2-Mg blood before treatment group compared with treatment in the control group β2-Mg treatment had no significant change. Conclusion Integrative treatment of diabetic nephropathy significant effect, can reduce renal damage, delay the deterioration of renal function, protect the kidneys, thereby slowing the course of diabetic nephropathy.