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目的:探讨归芍地黄汤联合溴隐亭治疗抗精神药物所致的药源性闭经的临床效果。方法:选择86例抗精神药物所致的药源性闭经患者为研究对象,随机分为治疗组和对照组。两组均予溴隐亭口服,治疗组在此基础上,给予口服归芍地黄汤,以两周为1个疗程,连续治疗3个疗程。观察记录两组患者月经情况,比较分析两组患者治疗前后内分泌指标变化及治疗期间出现的不良反应,并对患者随访半年,了解停药后复发情况。结果:治疗组总有效率为93.0%,对照组为72.1%,治疗组优于对照组(P<0.05);两组PRL指标治疗后均出现显著降低(P<0.05),而LH和E2指标均出现显著升高(P<0.05);两组治疗后比较,治疗组治疗后PRL指标显著低于对照组(P<0.05),而LH和E2指标显著高于对照组(P<0.05);在复发率随访调查中,治疗组复发率为4.3%,显著低于对照组复发率18.8%(P<0.05);两组均未见严重不良反应。结论:归芍地黄汤联合溴隐亭治疗抗精神药物所致的药源性闭经,能够协同发挥治疗作用,明显提高疗效,改善患者临床症状和血清内分泌水平,安全有效。
Objective: To investigate the clinical efficacy of Guishao Dihuang Decoction combined with bromocriptine in the treatment of drug-induced amenorrhea caused by antipsychotic drugs. Methods: Drug-induced amenorrhea induced by 86 antipsychotic drugs was selected as the research object and randomly divided into treatment group and control group. Both groups were given bromocriptine orally, on the basis of which the treatment group was given oral Guishao Dihuang Decoction, taking two weeks as a course of treatment and three courses of continuous treatment. Observe and record the menstrual situation of two groups of patients. Compare the changes of endocrine index before and after treatment and adverse reactions during the treatment in both groups, and follow-up of patients for six months to understand the relapse after discontinuation. Results: The total effective rate was 93.0% in the treatment group and 72.1% in the control group, the treatment group was superior to the control group (P <0.05). The PRL index of both groups decreased significantly (P <0.05) (P <0.05). After treatment, the PRL index of the treatment group was significantly lower than that of the control group (P <0.05), while the LH and E2 indexes were significantly higher than those of the control group (P <0.05). In the follow-up survey of relapse rate, the recurrence rate of the treatment group was 4.3%, which was significantly lower than that of the control group (18.8%, P <0.05). No serious adverse reactions were found in both groups. Conclusion: Guishao Dihuang Decoction combined with bromocriptine in the treatment of drug-induced amenorrhea induced by antipsychotic drugs can play a synergistic therapeutic effect, improve the curative effect and improve the clinical symptoms and serum endocrine levels of patients. It is safe and effective.