Synthesis of water-soluble cystine C_(60) derivative with catalyst and its active oxygen radical sca

• 出 处: Chinese Chemical Letters
• 发表日期: 2007年01期
• 关键词: scavenging derivative hydroxyl hydroxide anion eliminating dissolved substituent

A novel water-soluble cystine C_(60)derivative was synthesized in the presence of the catalyst,tetrabutylammonium hydroxide (TBAH).The product was characterized by FT-IR,UV,~1H NMR,~(13)C NMR,MS and elemental analysis.Furthermore,the scavenging ability to superoxygen anion radical O_2~(·-)and hydroxyl radical ~·OH was studied by chemiluminescence.It was found that cystine C_(60)derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical.The 50% inhibition concentration(IC_(50))for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg/mL,respectively.

A novel water-soluble cystine C_ (60) derivative was synthesized in the presence of the catalyst, tetrabutylammonium hydroxide (TBAH). The product was characterized by FT-IR, elemental analysis.Furthermore, the scavenging ability to superoxygen anion radical O_2 ~ (-) and hydroxyl radical ~ · OH was studied by chemiluminescence. It was found that cystine C_ (60) derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical. The 50% inhibition concentration (IC 50) for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg / mL, respectively.