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观察了不同剂量的商陆皂甙对大鼠幽门结扎型、醋酸型及小鼠利血平型胃溃疡的影响。实验结果,商陆皂甙A组(180mg/kg)对三种胃溃疡的溃疡指数分别为056±053(面积mm2);718±339(面积mm2),336±127(容积μl);167±218(小溃疡),178±211(出血点),比对照组小,(P<005)。溃疡抑制率分别为67%;5444%(面积mm2),5589%(容积μ1);844%(小溃疡),838%(出血点)。提示:商陆皂甙(180mg/kg)对胃溃疡有一定抑制作用。
The effects of different doses of pokeweed saponin on pyloric ligating, acetic acid and reserpine-induced gastric ulcers in rats were observed. As a result of the experiment, the ulcer index of three types of stomach ulcers in the meropenem group A (180mg/kg) was 056±053 (area mm2); 718±339 (area mm2), 336 ±127 (volume μl); 167±218 (small ulcer), 178±211 (bleeding point), smaller than the control group (P<005). The ulcer inhibition rates were 67%; 54.4% (area mm2), 55.89% (volume μ1); 84.4% (small ulcers), 83.8% (bleeding points). Tip: Pokeweed saponin (180mg/kg) has a certain inhibitory effect on gastric ulcer.