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环孢素(CsA)对肾移植病人糖代谢的副作用已有报道,但这些研究所采用的免疫抑制剂均包含类固醇激素,而本研究单独应用CsA以评价肾移值病人胰腺分泌功能,为纯CsA对糖代谢影响的研究提供了可能性。从1982年～1988年504例肾移植病人中筛选,凡符合下列条件列为候选:无糖尿病家族史,年龄20～45岁,标准体重的20%以内,肝功能正常,血肌酐<2mg/dl,肾移植时间>1年,无急性胰腺炎史,术后随访期间空腹血糖正常。将病人分成三组:
The side effects of cyclosporine (CsA) on glycometabolism in renal transplant patients have been reported, but the immunosuppressive agents used in these studies all contain steroid hormones. However, in this study, CsA alone was used to evaluate pancreatic secretion in patients with renal transplant and was pure The study of the effects of CsA on glucose metabolism offers the possibility. From 1982 to 1988, 504 cases of renal transplant patients were screened, where the following conditions were eligible as a candidate: a family history of no diabetes, aged 20 to 45 years, less than 20% of standard weight, normal liver function, serum creatinine <2mg / dl , Kidney transplantation> 1 year, no history of acute pancreatitis, normal fasting blood glucose during follow-up. The patients were divided into three groups: