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目的 :研究垂体腺瘤的临床激素过多症状与腺瘤组织激素检测之间的关系以及该病的发生、生物学行为、分类。方法 :对 180例垂体腺瘤进行了临床病理分析 ,并对其中 110例应用免疫组化ABC法检测了肿瘤的GH、PRL、ACTH、TSH、FSH、LH。结果 :临床激素过多症状与激素检测相一致者占 40 % ,且女性较男性相一致者多 ,差异有显著性。免疫组化分型以PRL和GH腺瘤多见 ,多激素腺瘤以GH +PRL腺瘤多见。结论 :垂体腺瘤的免疫组化检测与形态功能相结合的分类方法简便易行较为实用。
Objective: To study the relationship between the clinical symptoms of hyperalgesia in pituitary adenomas and the detection of tissue hormones in adenomas, as well as the occurrence, biological behavior and classification of the disease. Methods: A clinical pathological analysis was performed on 180 cases of pituitary adenomas. Among them, GH, PRL, ACTH, TSH, FSH, and LH were detected in 110 cases using immunohistochemical ABC method. Results: The proportion of clinical hormone excess and hormonal tests were 40%, and there were more women than men. The difference was significant. Immunohistochemical typing was more common in PRL and GH adenomas, and multihormone adenomas were more common in GH + PRL adenomas. Conclusion: The classification method of immunohistochemical detection combined with morphological function of pituitary adenoma is simple and practical.