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目的探讨HIV阳性和阴性肺结核患者血清锌和白蛋白水平测定的意义。方法以HIV阳性(n=24)和阴性(n=26)活动性肺结核患者为研究对象,共50例,20例健康志愿者为对照组。分别测定所有患者及对照组血清锌和白蛋白水平,并对结果进行统计学分析。结果HIV阳性和阴性活动性肺结核患者及对照组血清锌测定值分别为:(5.4±1.08)μmol/L,(10.2±0.97)μmol/L,(17.8±0.86)μmol/L;与对照组比较,阳性和阴性组患者的血清锌水平均明显下降(P<0.001和P<0.01),而且,阳性组低于阴性组(P<0.002);HIV阳性和阴性活动性肺结核患者及对照组血清白蛋白测定值分别为:(26.3±12.1)g/L,(39.8±11.4)g/L,(44.2±10.5)g/L;与对照组比较,阳性和阴性组患者的血清白蛋白水平均下降,但阴性组与对照组差异无显著性(P>0.05),而阳性组与阴性组和对照组比较,均有显著差异性(P<0.05和P<0.01)。结论HIV阳性活动性肺结核患者的营养状态非常差,对这些患者补充锌和白蛋白治疗是必要的。
Objective To investigate the significance of serum zinc and albumin levels in HIV-positive and -negative pulmonary tuberculosis patients. Methods HIV-positive (n = 24) and negative (n = 26) active tuberculosis patients were studied in 50 patients and 20 healthy volunteers as control group. Serum zinc and albumin levels were measured in all patients and controls, and the results were statistically analyzed. Results The serum zinc levels in patients with positive and negative HIV-positive pulmonary tuberculosis and control group were (5.4 ± 1.08) μmol / L, (10.2 ± 0.97) μmol / L and (17.8 ± 0.86) μmol / L, (P <0.001 and P <0.01), and the positive group and the negative group were significantly lower than those in the negative group (P <0.002). The serum levels of serum zinc in both HIV-positive and negative-active pulmonary tuberculosis patients and the control group (26.3 ± 12.1) g / L, (39.8 ± 11.4) g / L, and (44.2 ± 10.5) g / L, respectively. Compared with the control group, serum albumin levels in both positive and negative groups decreased , But there was no significant difference between the negative group and the control group (P> 0.05). However, there was significant difference between the negative group and the negative group and the control group (P <0.05 and P <0.01). Conclusions The nutritional status of HIV-positive patients with active pulmonary tuberculosis is very poor and is necessary for zinc and albumin supplementation in these patients.