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目的观察沙利度胺联合化疗及鞘注化疗药物治疗多发性骨髓瘤的疗效。方法确诊多发性骨髓瘤患者24例,小剂量沙利度胺联合VCMP方案:沙利度胺50 mg,2次/d口服,VCMP方案化疗,每月一疗程,其中18例患者化疗时鞘注甲氨蝶呤及地塞米松治疗。结果完全缓解4例,部分缓解12例,进步6例,总有效率91.7%。高于标准MP方案。结论小剂量沙利度胺联合VCMP方案化疗及鞘注化疗药物,治疗多发性骨髓瘤不良反应少,有效率高,颅内复发率低。
Objective To observe the efficacy of thalidomide combined with chemotherapy and intrathecal chemotherapy in the treatment of multiple myeloma. Methods Twenty-four patients with multiple myeloma were diagnosed. The low-dose thalidomide combined with VCMP regimen was given thalidomide 50 mg twice daily with VCMP regimen once a month, of which 18 patients underwent chemotherapy with intrathecal injection Methotrexate and dexamethasone treatment. The results of complete remission in 4 cases, partial remission in 12 cases, progress in 6 cases, the total effective rate was 91.7%. Higher than the standard MP program. Conclusion Low-dose thalidomide combined with VCMP chemotherapy and intrathecal chemotherapy drugs for the treatment of multiple myeloma with fewer adverse reactions, high efficiency, low recurrence rate.