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1991年4～11月,广州市发生了两个血清型别的登革热流行,病例数258例,发病率4.35/10万;死亡3例,病死率1.17%。前期以散发的登革Ⅳ型为主,后期呈局部性登革Ⅰ型病毒流行。在分离到的51株登革病毒中,登革Ⅰ型病毒45株,Ⅳ型6株。123例双份血清补结试验结果表明,有74例恢复期血清抗体滴度≥4倍升高,其中Den-1为60例,Den-4为14例。DHF/DSS病例占9.67%。实践证明,广州市对登革热流行采取的预防监测系统的控制措施,已达到监测散发病例的水平,两个血清型别的流行在国内尚属首次。
From April to November 1991, two serotypes of Dengue Fever occurred in Guangzhou City. The number of cases was 258, with an incidence rate of 4.35 / 100 000. There were 3 deaths and the case fatality rate was 1.17%. Dendritic cells distributed mainly in the early stage of type Ⅳ, followed by a localized dengue type I virus. Among the 51 dengue viruses isolated, 45 strains were dengue type I virus and 6 strains were type Ⅳ. 123 cases of double serum test results showed that 74 cases of convalescent serum antibody titer ≥4 times higher, including Den-1 was 60 cases, Den-4 was 14 cases. DHF / DSS cases accounted for 9.67%. Practice has proved that Guangzhou City, prevention and control of dengue epidemic prevention and control measures taken to monitor the level of surveillance has reached the level of distribution, the two serotypes of the epidemic in China for the first time.