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取重1.4～4kg的家兔,制成了更加接近人眼PVR的模型。在注入纤维母细胞之前24小时,对21眼注入甾族化合物,18眼仅注入基本药剂以作对照。甾族化合物投药组视网膜脱离的频率为43%,对照组为85%,取得显著效果。指出:以治疗和预防为目的使用甾族化合物时,可在手术前投药,且以局部浓度起决定作用。高浓度的眼内甾族化合物,抑制PVR的效果是肯定的。仅全身投药几乎没有抑制效果,眼内注射与全身投药并用,效果的增强也
Take 1.4 ~ 4kg rabbit, made more closer to human eye model of PVR. Twenty-one eyes were injected with steroids 24 hours prior to fibroblast injection, and only 18 of the 18 eyes were injected with the primary agent as a control. The frequency of retinal detachment was 43% in the steroid-administered group and 85% in the control group, with a significant effect. Pointed out: the treatment and prevention for the purpose of the use of steroids, can be administered before surgery, and the local concentration play a decisive role. High concentrations of intraocular steroids, the effect of inhibiting PVR is affirmative. Only systemic administration almost no inhibitory effect, intraocular injection and systemic administration and use, the effect is also enhanced