论文部分内容阅读
本文比较抗多巴胺能药物舒必利(Sulpiride)的消旋体(100mg)、右旋体(50mg)和左旋体(50mg)肌注后对健康人胃酸和胃泌素分泌的影响。健康志愿者42例(男性27例,女性15例),平均40岁(24～53岁),其中21名分为三组,观察用药后胃酸分泌的变化;另21名分为三组观察药物对胃泌素分泌的影响。胃酸用0.1MNaOH 定量,胃泌素用放射免疫法测定。结果表明,舒必利的消旋体和左旋体对胃酸分泌无明显影响,其右旋体则可使胃酸分泌显著减少(基础胃酸分泌减少50%,五肽胃泌素刺激后的胃酸分泌减少35%)。饥饿血清胃泌素水平用药后均无改变,但用消旋体和左旋
This article compared the effects of the dopaminergic drugs Sulpiride racemic (100mg), dextromethorphan (50mg), and levamisole (50mg) on gastric acid and gastrin secretion in healthy individuals. 42 healthy volunteers (27 males and 15 females) with an average age of 40 (24-53 years). 21 of them were divided into three groups to observe changes of gastric acid secretion after medication. The other 21 patients were divided into three groups Effect on gastrin secretion. Gastric acid was quantified with 0.1 M NaOH and gastrin was measured by radioimmunoassay. The results showed that sulpiride and levocerexate gastric acid secretion had no significant effect, its right-handed body can significantly reduce gastric acid secretion (basal gastric acid secretion decreased by 50%, pentagastrin-induced gastric acid secretion decreased by 35% ). Starved serum gastrin levels were unchanged after treatment, but with racemic and levorotatory