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肿瘤的侵袭和转移是成功治疗肿瘤的最大障碍。越来越多的研究表明肿瘤细胞与细胞外基质(Extracellularmatrix,ECM)及其受体(含CAMs)，尤其是与基底膜的相互作用是侵袭转移过程的特征[1]。1 细胞外基质分类及性质[2] ECM是胶原蛋白和弹性蛋白的复合网络，包埋在蛋白多糖和
The invasion and metastasis of tumors are the biggest obstacles to successful treatment of tumors. More and more studies have shown that the interaction of tumor cells with extracellular matrix (ECM) and its receptors (including CAMs), especially with the basement membrane, is a feature of invasion and metastasis [1]. 1 Classification and properties of extracellular matrix [2] ECM is a complex network of collagen and elastin, embedded in proteoglycans and