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目的:观察预防性应用甲地孕酮减少食管癌化疗毒副反应的疗效.方法:将80例经病理学确诊、需行化疗治疗的食管癌患者随机分为2组,实验组(40例),对照组(40例).实验组方案:在每个化疗周期开始的前一天,给予甲地孕酮分散片口服,2次/d ,每次160mg,直到化疗结束后3天.对照组方案:仅常规化疗.观察2组患者消化道反应和骨髓抑制情况,以及体重等变化.结果:实验组恶心呕吐症状明显减轻,白细胞下降发生率低,体重减轻发生率低,与对照组比较有显著性差异.结论:食管癌患者在全身化疗期间,预防性应用甲地孕酮可有效减轻化疗的毒副反应,改善患者营养状态,提高患者治疗耐受性和依从性.“,”Objective: To observe the preventive use of megestrol acetate effect of decreasing toxicity of chemotherapy of esophageal cancerMethods: 80 cases of esophageal cancerpatients were randomly divided into pathological diagnosis, received chemotherapy treatment into 2 groups, experimental group (40 cases), control group (40 cases). The experimental group:the day before each chemotherapy cycle begins, giving megestrol tablets, 2 times /d, 160mg each time, until the end of 3 days after chemotherapy. Control group: routine chemotherapy scheme.2 groups were observed in patients with gastrointestinal reaction and bone marrow suppression, and body weight change.Results: the symptoms of nausea and vomiting was significantly reduced, the decrease of white blood cels occur rate is low, the weight loss rate was low, there is significant difference compared with the control group.Conclusion: Patients with esophageal cancer during the chemotherapy period, preventive application of megestrol acetate can effectively reduce the toxicity of chemotherapy, improve the nutritional status of patients, improve patient tolerance and compliance.