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我们于1996年～1997年使用干扰能(Iutronα-2b)治疗6例老年慢性丙型肝炎患者,现将治疗前后丙肝病毒核糖核酸(HCV-RNA)及血清谷丙转氨酶(ALT)的变化情况,报告如下。 1 对象及方法 1.1 病例选择 6例均为男性,病程短者3年,长者6年,系60～70岁老年患者,全部有输血史。 1.2 观察项目 治疗前检查B超、肝功能、乙肝血清学标志6项指标、HCV-RNA,治疗后每月复查1次肝功能,血象检查列为常规,用药时观察体温及其临床表现。 1.3 治疗方法 干扰能300万U,每周3次,皮下注射,疗程24～48周,停药后观察1年。 1.4 检查方法 HCV-RNA以逆转录-聚合酶链反应(RT-PCR)进行检测,试剂盒由华美生物技术有限公司提供。
We treated 6 elderly patients with chronic hepatitis C using interferon energy (Iutronα-2b) from 1996 to 1997. The changes of hepatitis C virus (HCV) RNA and serum alanine aminotransferase (ALT) The report is as follows. 1 Subjects and methods 1.1 Case Selection 6 cases were men, short duration of 3 years, 6 years of elderly, Department of 60 to 70-year-old elderly patients, all with blood transfusion history. 1.2 Observation items before treatment, B ultrasound, liver function, hepatitis B serological markers 6 indicators, HCV-RNA, once a month after treatment review of liver function, blood tests as a routine, medication observed body temperature and clinical manifestations. 1.3 Treatment Interference can 3000000 U, 3 times a week, subcutaneous injection, treatment of 24 to 48 weeks after stopping the observation of 1 year. 1.4 Inspection Methods HCV-RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) kit provided by China and the United States Biotechnology Co., Ltd..