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目的 探讨测定血清中血管内皮生长因子 (VEGF)的水平在卵巢上皮癌诊断中的价值及其与预后的关系。方法 以 41例卵巢上皮癌 (EOC)、10例卵巢交界性肿瘤 (BOT)及 2 5例良性卵巢肿瘤 (BET)患者为 3个研究组 ,2 0例正常人为对照组 ,用酶联免疫吸附 (EL ISA )法测定各组术前血清中的 VEGF水平。结果 (1) EOC、BOT、BET及正常对照组血清 VEGF中位数分别为 415 .0、312 .5、170、16 5 pg/ ml,上述各组的范围分别为 110～2 12 0、10 0～ 12 5 0、70～ 92 5、10 0～ 735 pg/ ml。 EOC组较 BET及正常对照组血清 VEGF水平升高 ,组间差异有显著性 (P<0 .0 5 ) ,BOT组亦比 BET组及正常对照组升高 (P<0 .0 5 )。 (2 )卵巢上皮癌中 ,肿瘤分化差者 (G3)血清VEGF水平高于肿瘤分化较好者 (G1,G2 ) (P<0 .0 5 ) ;术前血清 VEGF水平高者提示大网膜及淋巴结转移的可能性大 ,术后 3年存活者少。结论 血清 VEGF水平与卵巢癌的恶性行为有关 ,作为判断预后具有一定的价值。
Objective To investigate the value of serum vascular endothelial growth factor (VEGF) in the diagnosis of ovarian epithelial cancer and its relationship with prognosis. Methods Three study groups including 41 cases of epithelial ovarian cancer (EOC), 10 cases of borderline ovarian tumor (BOT) and 25 cases of benign ovarian tumor (BET) were enrolled in this study. Twenty normal controls were used as controls. Enzyme-linked immunosorbent assay (ELISA) method was used to determine the level of VEGF in preoperative serum of each group. Results (1) The median serum VEGF levels of EOC, BOT, BET and normal control group were 415.0,312.5,170,165 pg / ml respectively, and the ranges of the above groups were 110-2,120,10 0 ~ 125 0,70 ~ 92 5,10 0 ~ 735 pg / ml. The level of serum VEGF in EOC group was higher than that in BET and normal control group (P <0.05). The level of VEGF in BOT group was also higher than that in BET group and normal control group (P <0.05). (2) In patients with epithelial ovarian cancer, the level of serum VEGF in patients with poorly differentiated tumors (G3) was higher than those with well-differentiated tumors (G1 and G2) (P <0.05) And the possibility of lymph node metastasis, less survivors 3 years after surgery. Conclusion The serum level of VEGF is related to the malignant behavior of ovarian cancer, which has certain value as a prognostic value.